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Daily treatment with valacyclovir decreases the rate of HSV-2 transmission in discordant, heterosexual couples in which the source partner has a history of genital HSV-2 infection . Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Such couples should be encouraged to consider suppressive antiviral therapy as part of a strategy to prevent transmission, in addition to consistent condom use and avoidance of sexual activity during recurrences. Fanfair RN, Zaidi A, Taylor LD, Xu F, Gottlieb S, Markowitz L. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies.

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However, receiving oral sex from a person with an oral HSV-1 infection can result in getting a genital HSV-1 infection.Several ELISA-based serologic tests are FDA approved and available commercially.

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