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* Exception can be considered for multidose vials used for a single patient (e.g., allergy shots) if the manufacturer’s instructions state that the vial can be used for longer than 28 days.
The Centers for Disease Control and Prevention provides comprehensive information about vaccine storage and handling in their Storage and Handling Toolkit, available at gov/vaccines/hcp/admin/storage/toolkit/
This type of unit has severe temperature control and stability issues.
However, compact "purpose built" or "pharmacy grade" refrigerators and freezers that have been engineered to maintain even temperatures throughout the unit are available, and these are ideal for use in small offices.
Stand-alone units that only refrigerate or only freeze are recommended by CDC.This prevents contamination and reduces the likelihood of medication errors.CDC recommends the use of bins, baskets, or some other type of uncovered containers that allow for organization and air circulation for vaccines and diluents within the storage unit.On April 10, 2015, the Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control (PIDAC-IPC) updated the guidance on the use of multidose vials in Infection Prevention and Control for Clinical Office Practice.
This guidance was revised as a result of inquiries from health care providers from outpatient and inpatient settings to clarify when opened multidose vials should be discarded.
The use of multidose vials for injectable medications and vaccines increases the risk of transmission of blood-borne pathogens and bacterial contamination of the vial and should be avoided.